💊Pharmacology · Year 2
Pharmacodynamics — How Drugs Act on the Body
What drugs do to the body — receptors, enzymes, ion channels, and the mechanisms behind every drug you will ever prescribe.
⏱️Under 90 mins
📖15 sections
🧃Grasp Tonics included
✨Marable™ storytelling
🎓Teaching Receipt™
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What You'll Learn
✓The four drug target classes and how each produces drug effects
✓The four receptor superfamilies and their signalling timescales
✓Full agonists, partial agonists, antagonists, and inverse agonists
✓Potency vs efficacy — EC₅₀, Emax, and the therapeutic index
✓Second messenger systems — cAMP, IP₃/DAG, and calcium
✓Enzyme inhibition mechanisms — competitive vs irreversible
✓Ion channel pharmacology — local anaesthetics, CCBs, benzodiazepines
✓Receptor regulation — desensitisation, tolerance, withdrawal
✓Pharmacodynamic interactions — serotonin syndrome, QT prolongation
✓Adverse drug reactions — Rawlins-Thompson classification
✓Antibiotic mechanisms of action and resistance
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Source Textbooks
📖Katzung's Basic & Clinical Pharmacology
📖Lippincott Illustrated Reviews: Pharmacology
📖Rang & Dale Pharmacology
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Module Sections
0
The Marable™ — The Lock and the Key1
Introduction to Pharmacodynamics — Drug Targets & Mechanisms2
Receptors — Classification & Signal Transduction3
Agonists, Antagonists & Partial Agonists4
Dose-Response Relationships — Potency, Efficacy & the Therapeutic Index5
Second Messenger Systems & Signal Amplification6
Enzyme Inhibition as a Drug Mechanism7
Ion Channel Pharmacology8
Receptor Regulation — Desensitisation, Tolerance & Sensitisation9
Pharmacodynamic Drug Interactions10
Adverse Drug Reactions — Classification & Mechanisms11
Pharmacodynamics in Clinical Drug Classes12
Pharmacodynamics of Antimicrobials — Mechanisms of Action & Resistance13
Teaching Receipt™ — Pharmacodynamics14
Deep Dive — Allosteric Pharmacology, Biased Agonism & GPCR Drug DiscoveryDeep Dive✨
The Marable™ Approach + Grasp Tonics
This module begins with a story about a locksmith and a stranger with many keys — mapping drug-receptor interactions onto a world you already understand. Grasp Tonics throughout provide vivid analogies to solidify each pharmacodynamic concept.