Pharmacokinetics — Absorption, Distribution, Metabolism & Excretion

What the body does to a drug — from the first dose to the last trace eliminated. Covering Katzung, Lippincott & Rang and Dale.

⏱️Under 90 mins

📖15 sections

🧃Grasp Tonics included

✨Marable™ storytelling

🎓Teaching Receipt™

Begin Module

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What You'll Learn

✓Routes of administration and how they determine bioavailability

✓First-pass metabolism and why it matters for oral drugs

✓Volume of distribution, plasma protein binding, and the blood-brain barrier

✓Phase I (CYP450) and Phase II metabolism with key enzyme interactions

✓Renal excretion — filtration, secretion, reabsorption, and ion trapping

✓Half-life, clearance, steady state, and how to design a dosing regimen

✓Drug interactions at every step of ADME

✓Special populations — renal/hepatic failure, elderly, pregnancy

✓Therapeutic drug monitoring and non-linear pharmacokinetics

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Source Textbooks

📖Katzung's Basic & Clinical Pharmacology

📖Lippincott Illustrated Reviews: Pharmacology

📖Rang & Dale Pharmacology

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Module Sections

The Marable™ — The Journey of a Letter

Introduction to Pharmacokinetics — The Four Processes

Absorption — Routes of Administration

Absorption — Bioavailability & First-Pass Metabolism

Distribution — Volume of Distribution & Protein Binding

Drug Metabolism — Phase I & Phase II Reactions

Drug Metabolism — Enzyme Induction, Inhibition & Genetic Variation

Excretion — Renal Excretion & Other Routes

Pharmacokinetic Parameters — Half-Life, Clearance & Steady State

Drug Interactions — Pharmacokinetic Mechanisms

Special Populations — Renal Failure, Hepatic Failure, Elderly & Pregnancy

Therapeutic Drug Monitoring & Non-Linear Pharmacokinetics

Pharmacokinetics in Clinical Practice — Designing a Dosing Regimen

Teaching Receipt™ — Pharmacokinetics

Deep Dive — CYP Enzymes, Transporters & Pharmacogenomics in PracticeDeep Dive

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The Marable™ Approach + Grasp Tonics

This module begins with a story about a letter's postal journey — mirroring drug ADME. Throughout the sections, Grasp Tonics offer quick real-world analogies to lock in each concept before moving on.

Begin Module